Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”
Science 20 May 2011: Vol. 332 no. 6032 p. 917
Tan CS, Schoof EM*, Creixell P*, Pasculescu A, Lim WA, Pawson T, Bader GD, Linding R.
*: Equal Authorship
*: Equal Authorship
Su et al. claim GC content variation can largely explain the observed tyrosine frequency variation independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.
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