You are here: Home / Publications / Linding Lab, ICR [work from 2007-2010] / Positive selection of tyrosine loss in metazoan evolution.

Positive selection of tyrosine loss in metazoan evolution.

Science. 2009 Sep 25;325(5948):1686-8. Epub 2009 Jul 9.
Tan CS, Pasculescu A, Lim WA, Pawson T*, Bader GD*, Linding R*.

*: Equal Authorship


John Nash showed that within a complex system, individuals are best off if they make the best decision that they can, taking into account the decisions of the other individuals. Here, we investigate whether similar principles influence the evolution of signaling networks in multicellular animals. Specifically, by analyzing a set of metazoan species we observed a striking negative correlation of genomically encoded tyrosine content with biological complexity (as measured by the number of cell types in each organism). We discuss how this observed tyrosine loss correlates with the expansion of tyrosine kinases in the evolution of the metazoan lineage and how it may relate to the optimization of signaling systems in multicellular animals. We propose that this phenomenon illustrates genome-wide adaptive evolution to accommodate beneficial genetic perturbation.




[Supplemental Information]



[2009: Signaling Breakthroughs of the Year]

[Perspective - Science]

[Editors Choice - Science Signaling]

[Faculty of 1000 Evaluation]

[Research Highlight - Nature Reviews Genetics]


Document Actions

« March 2017 »