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Research News from the Rune Linding Research Group
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- Cell-Specific Information Processing in Segregating Cell Populations
- In this Research Article published in Science, we provide the first systems- and cell-specific network models of contact-initiated signaling between two distinct cell types.
- Commentary on Verification of systems biology research
- Collaborative competitions in which communities of researchers compete to solve challenges may facilitate more rigorous scrutiny of scientific results.
- Network Medicine Strikes a Blow against Breast Cancer
- Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.
- Positive Selection of Tyrosine Loss in Metazoan Evolution - Take Two
- Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”
